Alsya Affandi receives the prestigious Veni grant of 280,000 euros from The Dutch Research Council NWO, for his research in developing nanovaccines for treatment of cancer and autoimmunity.
Our immune system is key for protection against pathogens and malignant cells. Impairment of the immune system can lead to failure to clear viral or bacterial infection, or to prevent tumor development. On the other hand, uncontrolled immune responses can also lead to the development of chronic autoimmune diseases. Dendritic cells (DCs) are the master regulators of immune system with tremendous immunotherapy potential, however current DC-based therapies are still lacking effectiveness in treating these diseases.
To overcome this challenge, Alsya Affandi’s research proposal “Nanotrivax: three-component nanobody-vaccines targeting human dendritic cells for immunotherapy” aims to use nanobodies to deliver vaccine components specifically towards DCs.